Methyldrene 25 100 caps


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Cloma Pharma Methyldrene ECA is one of the strongest fat burners on the market of supplements for athletes. It contains only synergistically active ingredients, whose effectiveness has been confirmed by much scientific research. A powerful dose of the proprietary “ECA” mix makes it one of the leaders of this type of product.

ECA (Ephedrine, Caffeine, Aspirin) is a legendary combination of ingredients used for the purpose of maximum fat loss. It is a strong thermogenic agent consisting of ephedrine, caffeine, and acetylsalicylic acid. The effectiveness of ECA in weight loss is unquestionable and proved by a large number of clinical trials, as well as many years of experience of users and athletes.

The Cloma Pharma Methyldrene ECA consists of the following ingredients:

Ephedra viridis (leaf extract) – Ephedra plant species (Przęśl) containing naturally occurring alkaloids: ephedrine (approx. 90%), pseudoephedrine, and methylephedrine. Ephedrine belongs to the stimulant group stimulating the central and peripheral nervous system. It is a derivative of phenylethylamine (PEA) and is part of the ECA complex (ephedrine, caffeine, aspirin) that strongly burns fat.

The mechanism of ephedra action:
Ephedrine acts both directly on the activation of alpha and beta-adrenergic receptors (stimulating the sympathetic system as well as adrenaline), and indirectly through the release of noradrenaline from nerve endings. In addition, it stimulates the conversion (transformation) of the inactive form of the thyroid hormone T4 (thyroxine) into the active form T3 (triiodothyronine).

Slimming properties of ephedrine:
– strongly reduces appetite, reduces appetite
– accelerates the metabolic rate, thus energy expenditure
– intensifies thermogenesis, or the process of heat energy production
– stimulates the release of fat on fat cells
– raises motivation for physical activity and adds energy

Anhydrous caffeine – a purine alkaloid with a psychoactive effect, naturally occurring, among others about coffee, tea, guarana, yerba mate and cocoa, but also obtained synthetically. It belongs to the group of stimulants or substances that stimulate the activity of the sympathetic system and the central nervous system (CNS).

Caffeine increases the metabolism, that is, the overall energy transformation occurring in the body, and promotes lipolysis, ie the breakdown of triglycerides with adipose tissue. By blocking adenosine receptors, it counteracts sleepiness and reduces fatigue.

White willow bark – also called natural aspirin; contains salicin or natural acetylsalicylic acid. Together with about caffeine and ephedrine, it enters the composition of “ECA stack”, which is a complex that is extremely effective in burning back fat.

Salicylic acid has the ability to activate AMP-dependent kinase enzyme (AMPK), which increases the supply of energy substrates to muscle cells and intensifies their combustion. In connection with this, the energy expenditure of the body increases, fat loss is more important.

Bitter citrus extract (Citrus Aurantium Extract) – contains synephrine (a natural analog of ephedrine), which stimulates the sympathetic nervous system like adrenaline. It activates some of the adrenergic receptors: alpha-1 and beta-3, which causes lipolysis (decomposition of fats) with simultaneous activation of thermogenesis.

Synephrine is a natural substitute for ephedrine. It is more and more often added to supplements and preparations intended for athletes and obese people.

Correct / Korean ginseng (Panax ginseng) (root extract) – a medicinal plant used on Chinese medicine for almost 4000 years. It contains numerous flavonoids, nitrogen compounds, fatty acids, vitamins, and bioactive ginsenosides classified as saponins. It belongs to the group of adaptogens, ie herbal substances (extracts) supporting the body’s resistance to stress stimuli and traumatic experiences, used on states of fatigue or anxiety. It supports slimming through specific ability to lower blood glucose, improving insulin-glucose management.

Ginger root powder – contains szogaole and gingerol – polyphenols with a similar structure to noradrenaline and facilitate fat burning. It favors slimming because it is included in compounds intensifying thermogenesis, which by increasing the heat production, stimulate the energy expenditure of the body.

Hoodia Gordonii – a cultivar of the South African plant with the Hoodia family, occurring in the Kalahari desert. Its active compound is steroid glycosides (hoodigenin, calogenin) whose activity is not fully known by science. As an effective suppressant of hunger, it is recommended for people who want to reduce body fat by increasing the rate of metabolism.

Cayenne fruit extract – extracted from hot chili peppers; contains capsaicin (an alkaloid that acts on the vanilloid receptor). This results in the release of adrenaline and norepinephrine (catecholamines) from the adrenal medulla, resulting in increased metabolism and increased lipolysis.

Green tea extract – (Green tea leaf extract) – is a concentrate containing biologically active compounds: polyphenols (including catechin, EGCG – epigallocatechin gallate), showing antioxidant properties and low thermogenic potential.

Cocoa extract – derived from cocoa beans; contains theobromine – a purine alkaloid, which in combination with polyphenols and caffeine increases the thermogenic potential, allowing to increase energy expenditure and accelerate the reduction of body fat.

Yohimbe bark extract – contains yohimbine belonging to the group of alkaloids, which has stimulant properties. It selectively blocks alpha-2 adrenergic receptors, causing the adrenaline and norepinephrine to stimulate lipolysis – the process of triglyceride decomposition to fatty acids and glycerol, which in this form can be included in energy production processes.

Black Griffonia seed extract – contains 5-HTP (5-hydroxytryptophan) – an aromatic amino acid naturally produced by the body from an exogenous (essential) amino acid – l-tryptophan. Therapeutically used for over 30 years due to the specific ability to increase the production of serotonin in the brain.

Clinical studies on obese patients have shown that the use of 5-HTP resulted in a decrease in the amount of food intake (reduction of appetite), and thus a reduction in body weight.

All this makes 5-HTP prove very helpful during restrictive weight-loss diets, when both the amount of tryptophan and serotonin drops sharply, resulting in increased carbohydrate desire, and consequently excessive caloric intake or gluttony. 5-HTP counteracts the desire for carbohydrates (about this sweetness), and thus helps to reduce the appetite and the number of calories consumed.

In conclusion, Cloma Pharma Methyldrene ECA is an extremely effective fat burning that acts across various metabolic pathways. The preparation is intended only for advanced users and athletes due to the strongest composition of ingredients on the market.


1 capsule twice a day

Additional information

Weight 0,120 kg